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EnglishA tandem gold(I)-catalyzed aminocylization/fluorination and a two-step, one-pot gold(III)-catalyzed cyclization/electrophilic fluorination provide a convenient and general method for the synthesis of 3,3-difluoro-2-substituted-3H-indoles in good yield undermild conditions. Extension of the procedure to the synthesis of 2-aryl-3-fluoro-1H-indoles is described. The reaction proceeds smoothly in green ethanol and does not require any base, acid, or N-protective group.
| Titolo: | One-Pot Gold-Catalyzed Aminofluorination of Unprotected 2-Alkynylanilines |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Abstract: | A tandem gold(I)-catalyzed aminocylization/fluorination and a two-step, one-pot gold(III)-catalyzed cyclization/electrophilic fluorination provide a convenient and general method for the synthesis of 3,3-difluoro-2-substituted-3H-indoles in good yield undermild conditions. Extension of the procedure to the synthesis of 2-aryl-3-fluoro-1H-indoles is described. The reaction proceeds smoothly in green ethanol and does not require any base, acid, or N-protective group. |
| Handle: | http://hdl.handle.net/11697/10076 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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