Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington’s disease

Ciancarelli, Irene; Amicis, Daniela De; Massimo, Caterina Di; Scanno, Carla Di; Pistarini, Caterina; D’Orazio, Nicolantonio; Tozzi, MARIA GIULIANA

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Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington’s disease (HD). Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-20-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients. Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed. Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.

Titolo:	Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington’s disease
Autori:	CIANCARELLI, IRENE Amicis, Daniela De Massimo, Caterina Di Scanno, Carla Di Pistarini, Caterina D’Orazio, Nicolantonio TOZZI, MARIA GIULIANA mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	BIOMARKERS
Abstract:	Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington’s disease (HD). Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-20-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients. Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed. Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
Handle:	http://hdl.handle.net/11697/10109
Appare nelle tipologie:	1.1 Articolo in rivista

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