Oxidative stress has been found to be associated with the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium oxide nanoparticles (CNPs) have been studied as potent antioxidant agents able to exert neuroprotective effects. This work reports polyethylene glycol (PEG)-coated and antibody-conjugated CNPs for the selective delivering to A beta aggregates, and the protective effect against oxidative stress/A beta-mediated neurodegeneration. In this study PEG-coated and anti-A beta antibody-conjugated antioxidant nanoparticles (A beta-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. A beta-CNPs-PEG specifically targets the A beta aggregates, and concomitant rescue of neuronal survival better than A beta-CNPs, by modulating the BDNF signaling pathway. This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.

Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of A beta aggregates modulate neuronal survival pathways

CIMINI, Anna Maria;GENTILE, ROBERTA;BENEDETTI, ELISABETTA;MONACO, ANTONINA MARIA;SANTUCCI, Sandro;
2012

Abstract

Oxidative stress has been found to be associated with the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium oxide nanoparticles (CNPs) have been studied as potent antioxidant agents able to exert neuroprotective effects. This work reports polyethylene glycol (PEG)-coated and antibody-conjugated CNPs for the selective delivering to A beta aggregates, and the protective effect against oxidative stress/A beta-mediated neurodegeneration. In this study PEG-coated and anti-A beta antibody-conjugated antioxidant nanoparticles (A beta-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. A beta-CNPs-PEG specifically targets the A beta aggregates, and concomitant rescue of neuronal survival better than A beta-CNPs, by modulating the BDNF signaling pathway. This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/10165
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 119
  • ???jsp.display-item.citation.isi??? 119
social impact