The reaction of an enantiomerically pure sulfinimine of trifluoropyruvate with several metal enolates is described. The use of TiCl(O-iPr)3/LDA produced the corresponding sulfinamides with high stereocontrol. The latter could be smoothly transformed into each enantiomer of a-trifluoromethyl aspartic acid with high ee, which has been previously synthesized only in racemic form.
Titolo: | Stereoselective synthesis of (R)- and (S)--Tfm aspartic acid via titanium enolate addition to a sulfinimine of trifluoropyruvate |
Autori: | |
Data di pubblicazione: | 2004 |
Rivista: | |
Abstract: | The reaction of an enantiomerically pure sulfinimine of trifluoropyruvate with several metal enolates is described. The use of TiCl(O-iPr)3/LDA produced the corresponding sulfinamides with high stereocontrol. The latter could be smoothly transformed into each enantiomer of a-trifluoromethyl aspartic acid with high ee, which has been previously synthesized only in racemic form. |
Handle: | http://hdl.handle.net/11697/10260 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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