Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to β-lactamases in the presence of two β- lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a β-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A β-lactamase were susceptible to cefodizime in combination with clavulanic acid.
|Titolo:||In vitro activity of cefodizime (HR-221) in combination with β-lactamase inhibitors|
|Autori interni:||SEGATORE, Bernardetta|
|Data di pubblicazione:||1993|
|Rivista:||JOURNAL OF CHEMOTHERAPY|
|Appare nelle tipologie:||1.1 Articolo in rivista|