Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to β-lactamases in the presence of two β- lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a β-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A β-lactamase were susceptible to cefodizime in combination with clavulanic acid.
In vitro activity of cefodizime (HR-221) in combination with β-lactamase inhibitors
SEGATORE, Bernardetta;PERILLI, MARIAGRAZIA;FRANCESCHINI, Nicola;SETACCI, Domenico;ORATORE, Arduino;AMICOSANTE, Gianfranco
1993-01-01
Abstract
Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to β-lactamases in the presence of two β- lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a β-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A β-lactamase were susceptible to cefodizime in combination with clavulanic acid.File in questo prodotto:
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