Inducible β-lactamases were obtained after exposure to several β-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. β-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed.
|Titolo:||β-Lactamase induction antagonizes β-lactam susceptibilities in Citrobacter diversus and Enterobacter cloacae clinical isolates|
|Autori interni:||OLIVA, Brunello|
|Data di pubblicazione:||1991|
|Rivista:||JOURNAL OF CHEMOTHERAPY|
|Appare nelle tipologie:||1.1 Articolo in rivista|