Inducible β-lactamases were obtained after exposure to several β-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. β-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed.
β-Lactamase induction antagonizes β-lactam susceptibilities in Citrobacter diversus and Enterobacter cloacae clinical isolates
OLIVA, Brunello;FRANCESCHINI, Nicola;AMICOSANTE, Gianfranco
1991-01-01
Abstract
Inducible β-lactamases were obtained after exposure to several β-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. β-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed.File in questo prodotto:
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