A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate
PERILLI, MARIAGRAZIA;FIORE, MARIANNA;AMICOSANTE, Gianfranco
2005-01-01
Abstract
A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134. Copyright © 2005, American Society for Microbiology. All Rights Reserved.File in questo prodotto:
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