The interaction between meropenem and class A, B, C and D β-lactamases was studied by a spectrophotometric method. Class A, C and D β-lactamases were unable to confer in vitro resistance to carbapenems. Surprisingly, several class B metallo-β-lactamases expressed in Escherichia coli failed to confer resistance when a conventional inoculum (105 cfu/mL) was used.
Meropenem stability to β-lactamase hydrolysis and comparative in vitro activity against several β-lactamase-producing Gram-negative strains
FRANCESCHINI, Nicola;SEGATORE, Bernardetta;PERILLI, MARIAGRAZIA;AMICOSANTE, Gianfranco
2002-01-01
Abstract
The interaction between meropenem and class A, B, C and D β-lactamases was studied by a spectrophotometric method. Class A, C and D β-lactamases were unable to confer in vitro resistance to carbapenems. Surprisingly, several class B metallo-β-lactamases expressed in Escherichia coli failed to confer resistance when a conventional inoculum (105 cfu/mL) was used.File in questo prodotto:
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