A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazidime) and aztreonam. Expression of blaTEM-87 in Escherichia coli decreased the host susceptibility to these drugs.

Characterization of a new extended-spectrum β-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey

PERILLI, MARIAGRAZIA;SEGATORE, Bernardetta;DE MASSIS, MARIA ROSARIA;FRANCESCHINI, Nicola;AMICOSANTE, Gianfranco
2002-01-01

Abstract

A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazidime) and aztreonam. Expression of blaTEM-87 in Escherichia coli decreased the host susceptibility to these drugs.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/103154
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