Background and aim. Matrix metalloproteinases (MMPs) are a family of endopeptidases produced by cytokine-stim- ulated lamina propria mononuclear cells (LPMCs) and myofibroblasts, playing a key role in tissue remodelling in both physiological and pathological conditions. Till now, a quantitative assessment of MMP expression in coeliac disease (CD) has never been performed. Therefore, the aim of the present study was to characterise the MMP pattern in LPMCs isolated from coeliac duodenal mucosa in comparison to normal condition, and to investigate the putative influence of the two main Th1 cytokines, IFN-g and TNF-, on their expression.
X national Congress of digestive diseases - Italian federation of digestive disease, Turin, 27-31 march 2004
PISTOIA, Maria Antonietta;CIFONE, MARIA GRAZIA;
2004
Abstract
Background and aim. Matrix metalloproteinases (MMPs) are a family of endopeptidases produced by cytokine-stim- ulated lamina propria mononuclear cells (LPMCs) and myofibroblasts, playing a key role in tissue remodelling in both physiological and pathological conditions. Till now, a quantitative assessment of MMP expression in coeliac disease (CD) has never been performed. Therefore, the aim of the present study was to characterise the MMP pattern in LPMCs isolated from coeliac duodenal mucosa in comparison to normal condition, and to investigate the putative influence of the two main Th1 cytokines, IFN-g and TNF-, on their expression.File in questo prodotto:
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