PGD2, IL-1-family members and mast cells

Anogeianaki, A; Castellani, Ml; Tripodi, D; Felaco, P; Toniato, E; De Lutiis, Ma; Fulcheri, M; Tete, S; Galzio, R; Salini, V; Caraffa, A; Antinolfi, P; Frydas, I; Sabatino, G; Shaik-Dasthagirisaheb, Yb

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Cytokines are immunomodulatory and inflammatory compounds produced by many different Cell types The IL-1 family consists of at least eleven cytokines. including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4 Here we review the interrelationship between PGD2, IL-1 family members and mast cells

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/10539

Titolo:	PGD2, IL-1-family members and mast cells
Autori interni:	GALZIO, RENATO
Data di pubblicazione:	2010
Rivista:	EUROPEAN JOURNAL OF INFLAMMATION
Abstract:	Cytokines are immunomodulatory and inflammatory compounds produced by many different Cell types The IL-1 family consists of at least eleven cytokines. including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4 Here we review the interrelationship between PGD2, IL-1 family members and mast cells
Handle:	http://hdl.handle.net/11697/10539
Appare nelle tipologie:	1.1 Articolo in rivista

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