The effect of transurethral microwave thermotherapy (TUMT) with Prostatron in patients with benign prostatic hypertrophy was investigated. Two hundred and one patients were treated between January 1991 and June 1992 after informed consent was signed. The following examinations were carried out at screening: interview (including symptom score evaluation), physical examination (including digital rectal examination), haematology and blood chemistry (including prostate specific antigen), ECG, chest Xray, kidney, bladder and prostate (transrectal) ultrasound sonography (USS) and uroflowmetry; pressure-flow study was performed in a selected group of patients. All enrolled patients had Madsen symptom score ≥ 8; peak flow rate ≤ 15 ml/s and post void residual urine ≤ 200 ml. Patients with obstructive middle lobe of the prostate, any BPH complication or any suspicion of prostatic carcinoma were excluded from the study. Microwave thermotherapy with Prostatron was carried out according to software generation 2.0 (Prostasoft 2.0), the c10 (black) catheter was used in all patients. Follow-up visits were scheduled at 1 week, 1, 3, 6, 12, 18 months after microwave thermotherapy. Overall short- and long-term morbidity rates were 6.09 and 2.73 per cent, respectively. At 12 months, Madsen score was found to be reduced from 11.7 ± 4.78 to 4.43 ± 3.30; maximum flow rate (Qmax) was increased from 8.91 ± 4.20 to 13.20 ± 4.86; post void residual urine (PVRU) was reduced from 131 ± 17.6 to 67.40 ± 34.50. Pressure-flow study showed no modificafion of the minimal urethral opening pressure (pmuo) at 6 months: from 38.40 ± 14.00 to 34.20 ± 6.14 cm H2O; slope value (P/F2) decreased from 2.85 ± 2.35 to 1.26 ± 1.17. Increased elasticity of prostatic urethra was observed after treatment resulting in a shift of the linear passive urethral resistance relation (PURR). Best therapeutic response occurred in patients with mild prostatic obstruction.

LA THERMOTHERAPIE TRANSURETRALE PAR MICRO-ONDES CHEZ LES PATIENTS AYANT UNE HYPERTROPHIE PROSTATIQUE BENIGNE OBSTRUCTIVE

TUBARO, ANDREA;PARADISO GALATIOTO, Giuseppe;
1993-01-01

Abstract

The effect of transurethral microwave thermotherapy (TUMT) with Prostatron in patients with benign prostatic hypertrophy was investigated. Two hundred and one patients were treated between January 1991 and June 1992 after informed consent was signed. The following examinations were carried out at screening: interview (including symptom score evaluation), physical examination (including digital rectal examination), haematology and blood chemistry (including prostate specific antigen), ECG, chest Xray, kidney, bladder and prostate (transrectal) ultrasound sonography (USS) and uroflowmetry; pressure-flow study was performed in a selected group of patients. All enrolled patients had Madsen symptom score ≥ 8; peak flow rate ≤ 15 ml/s and post void residual urine ≤ 200 ml. Patients with obstructive middle lobe of the prostate, any BPH complication or any suspicion of prostatic carcinoma were excluded from the study. Microwave thermotherapy with Prostatron was carried out according to software generation 2.0 (Prostasoft 2.0), the c10 (black) catheter was used in all patients. Follow-up visits were scheduled at 1 week, 1, 3, 6, 12, 18 months after microwave thermotherapy. Overall short- and long-term morbidity rates were 6.09 and 2.73 per cent, respectively. At 12 months, Madsen score was found to be reduced from 11.7 ± 4.78 to 4.43 ± 3.30; maximum flow rate (Qmax) was increased from 8.91 ± 4.20 to 13.20 ± 4.86; post void residual urine (PVRU) was reduced from 131 ± 17.6 to 67.40 ± 34.50. Pressure-flow study showed no modificafion of the minimal urethral opening pressure (pmuo) at 6 months: from 38.40 ± 14.00 to 34.20 ± 6.14 cm H2O; slope value (P/F2) decreased from 2.85 ± 2.35 to 1.26 ± 1.17. Increased elasticity of prostatic urethra was observed after treatment resulting in a shift of the linear passive urethral resistance relation (PURR). Best therapeutic response occurred in patients with mild prostatic obstruction.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/107721
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