We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63-year-old man. Neuroendocrine cancer was resistant to various conventional treatments and following locoregional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of >75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.
|Titolo:||Chronic lymphocytic leukaemia and neuroendocrine cancer|
|Autori interni:||GUADAGNI, Stefano|
|Data di pubblicazione:||1999|
|Rivista:||BRITISH JOURNAL OF HAEMATOLOGY|
|Appare nelle tipologie:||1.1 Articolo in rivista|