Background: CH-40 is a suspension of activated carbon particles that was developed in Japan to carry anticancer drugs to regional nodes and peritoneal seedings of gastric cancer. Methods: Forty-five consecutive patients who had surgical resection and D2 lymph node dissection for gastric cancer over a 2- year period were randomly assigned to preoperative endoscopic submucosal injection of CH-40 (group A) or no staining (group B). A total of 21 patients in group A and 24. in group B were available for analysis. Results: The number of resected nodes per patient was significantly higher (t = 6.06; 40 df; P < .0001) in group A (mean ± S.E. = 35.3 ± 1.24) than in group B (mean ± S.E. = 25.5 ± 1.02). The rate of metastatic nodes resected was significantly higher (X2 = 6.903 ; 1 df; P = .009) in stained (22.5%) than in non-stained (14.7%) nodes of group A and also (X2 = 6.906 ; 1 df; P = .009) in stained nodes of group A than in group B (15.8%). Conclusions: Preoperative endoscopic vital staining with CH-40 proved to be rapid, safe, and effective in all cases in this series. Its use allowed surgeons to resect a higher number of lymph nodes, and to identify and examine more metastatic nodes. It also permitted identification of nodal micrometastases on routine histopathologic examination.

Prospective randomized evaluation of preoperative endoscopic vital staining using CH-40 for lymph node dissection in gastric cancer

GUADAGNI, Stefano;PISTOIA, Maria Antonietta;
1998-01-01

Abstract

Background: CH-40 is a suspension of activated carbon particles that was developed in Japan to carry anticancer drugs to regional nodes and peritoneal seedings of gastric cancer. Methods: Forty-five consecutive patients who had surgical resection and D2 lymph node dissection for gastric cancer over a 2- year period were randomly assigned to preoperative endoscopic submucosal injection of CH-40 (group A) or no staining (group B). A total of 21 patients in group A and 24. in group B were available for analysis. Results: The number of resected nodes per patient was significantly higher (t = 6.06; 40 df; P < .0001) in group A (mean ± S.E. = 35.3 ± 1.24) than in group B (mean ± S.E. = 25.5 ± 1.02). The rate of metastatic nodes resected was significantly higher (X2 = 6.903 ; 1 df; P = .009) in stained (22.5%) than in non-stained (14.7%) nodes of group A and also (X2 = 6.906 ; 1 df; P = .009) in stained nodes of group A than in group B (15.8%). Conclusions: Preoperative endoscopic vital staining with CH-40 proved to be rapid, safe, and effective in all cases in this series. Its use allowed surgeons to resect a higher number of lymph nodes, and to identify and examine more metastatic nodes. It also permitted identification of nodal micrometastases on routine histopathologic examination.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/110409
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