66 biliopathic subjects were selected for this study: 46 of them affect by simple gallbladder calculosis, 20 by gall-duct calculosis and/or papillary stenosis. Patients were devided in 2 groups: Group A (21 gallbladder calculosis, 10 gall-duct calculosis and/or papillary stenosis); Group B (25 simple gallbladder calculosis, 10 gall-duct calculosis and/or papillary stenosis). 3 hours before surgery 400 mg (2 tables) of Ofloxacin were administered orally to the Group A patients. Group B patients underwent antibiotic therapy with 2 g every 12 hrs. of Ampicillin. From the microbiological analysis carried out on biliary serum and samples (gallbladder and gall-duct bile) 3 hrs. after administration, it was verified that Ofloxacin is distributed in the bile in sufficient therapeutical quantities to inhibit microbial growth of both anaerobic and aerobic bacteria. The mean value of the total bacterial change of group A patients (treated with Ofloxacin) was significatively lower than that determined in group B patients (treated with Ampicillin). Even from the clinical point of view there was a reduced post-surgery time interval, a reduced hospitalization and temperature duration. There were no particular side-effects; an increase of eosinophils was registered in a single subject which was however affected, by a conjoint pathology (chronic alcoholic hepatopathy).

STUDIO CLINICO SULL'UTILIZZAZIONE DELL'OFLOXACIN (DL-8280) IN CHIRURGIA BILIARE

GUADAGNI, Stefano;PISTOIA, Maria Antonietta;
1985

Abstract

66 biliopathic subjects were selected for this study: 46 of them affect by simple gallbladder calculosis, 20 by gall-duct calculosis and/or papillary stenosis. Patients were devided in 2 groups: Group A (21 gallbladder calculosis, 10 gall-duct calculosis and/or papillary stenosis); Group B (25 simple gallbladder calculosis, 10 gall-duct calculosis and/or papillary stenosis). 3 hours before surgery 400 mg (2 tables) of Ofloxacin were administered orally to the Group A patients. Group B patients underwent antibiotic therapy with 2 g every 12 hrs. of Ampicillin. From the microbiological analysis carried out on biliary serum and samples (gallbladder and gall-duct bile) 3 hrs. after administration, it was verified that Ofloxacin is distributed in the bile in sufficient therapeutical quantities to inhibit microbial growth of both anaerobic and aerobic bacteria. The mean value of the total bacterial change of group A patients (treated with Ofloxacin) was significatively lower than that determined in group B patients (treated with Ampicillin). Even from the clinical point of view there was a reduced post-surgery time interval, a reduced hospitalization and temperature duration. There were no particular side-effects; an increase of eosinophils was registered in a single subject which was however affected, by a conjoint pathology (chronic alcoholic hepatopathy).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/110749
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