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EnglishIn the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats. This study shows that the combined administration of Diflunisal and Indomethacin exerts similar anti-inflammatory activity as the single drugs. There does not seem to be additive anti-inflammatory effects of the drugs in combination but, if anything, a weak antagonism. The association of the two compounds produces a reduced harmful effect on the gastric mucus.
http://hdl.handle.net/11697/11280| Titolo: | "Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa |
| Autori interni: | CIFONE, MARIA GRAZIA CONTINENZA, Maria Adelaide ALESSE, Edoardo |
| Data di pubblicazione: | 1980 |
| Rivista: | BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE |
| Abstract: | In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats. This study shows that the combined administration of Diflunisal and Indomethacin exerts similar anti-inflammatory activity as the single drugs. There does not seem to be additive anti-inflammatory effects of the drugs in combination but, if anything, a weak antagonism. The association of the two compounds produces a reduced harmful effect on the gastric mucus. |
| Handle: | http://hdl.handle.net/11697/11280 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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