First Synthesis of Totally Orthogonal Protected
alpha-(Trifluoromethyl)- and alpha-(Difluoromethyl)arginines

Maurizio, Moroni; Beate, Koksch; Osipov, Sergey N.; Crucianelli, Marcello; Massimo, Frigerio; Pierfrancesco, Bravo; Klaus, Burger

doi:10.1021/jo0009043

The first synthesis of a series of totally orthogonal protected racemic R-(trifluoromethyl)- and R-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.

Titolo:	First Synthesis of Totally Orthogonal Protected alpha-(Trifluoromethyl)- and alpha-(Difluoromethyl)arginines
Autori:	Maurizio Moroni Beate Koksch Sergey N. Osipov CRUCIANELLI, MARCELLO Massimo Frigerio Pierfrancesco Bravo Klaus Burger mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2001
Rivista:	JOURNAL OF ORGANIC CHEMISTRY
Abstract:	The first synthesis of a series of totally orthogonal protected racemic R-(trifluoromethyl)- and R-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.
Handle:	http://hdl.handle.net/11697/11601
Appare nelle tipologie:	1.1 Articolo in rivista

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