The first synthesis of a series of totally orthogonal protected racemic R-(trifluoromethyl)- and R-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.

First Synthesis of Totally Orthogonal Protected alpha-(Trifluoromethyl)- and alpha-(Difluoromethyl)arginines

CRUCIANELLI, MARCELLO;
2001

Abstract

The first synthesis of a series of totally orthogonal protected racemic R-(trifluoromethyl)- and R-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/11601
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