The aza-Wittig reaction of phospha&5-azenes with optically pure y-fluorosubstituted I~- ketosulfoxides leads to the corresponding 13-enaminosulfoxides, which were easily isolated in diastereomerically pure form. The stercoselective reduction of the enamine 3cb afforded the optically pure [~-sulphinyl-amine5 cb in high overall yield.
Stereoselective Synthesis of Optically Pure gamma-Fluoro-beta-Enaminosulfoxides and Reduction to gamma-Fluoro-beta-Aminosulfoxides
CRUCIANELLI, MARCELLO;
1995-01-01
Abstract
The aza-Wittig reaction of phospha&5-azenes with optically pure y-fluorosubstituted I~- ketosulfoxides leads to the corresponding 13-enaminosulfoxides, which were easily isolated in diastereomerically pure form. The stercoselective reduction of the enamine 3cb afforded the optically pure [~-sulphinyl-amine5 cb in high overall yield.File in questo prodotto:
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