The enantioselective synthesis of chiral non-racemic alpha,alpha-N,S-disubstituted ketals of beta-fluoro-pyruvaldehydes 2 has been efficiently accomplished by one-per treatment of the gamma-fluoro-beta-enaminosulfoxides 1 with trifluoroacetic anhydride and then with silica gel. Two fast and enantioselective rearrangements should be involved in the reaction. A change of reaction conditions or the use of other promoters, like acyl chlorides, can produce achiral vinyl sulfides.
File in questo prodotto:
Non ci sono file associati a questo prodotto.