An aldol-reduction one-pot sequence allows syn-syn polyketide fragments such as 7 to be obtained enantio and diastereoselectively. Enol Diisopinocampheylborinate is able to influence both the aldol and the subsequent reduction with NaBH4, via a chelate chair like intermediate.

Boron Mediated One-Pot Aldol-reduction Sequence: Enantio and Diastereoselective Synthesis of Typical Polyketide Fragments

ROSSI, LEUCIO
1994

Abstract

An aldol-reduction one-pot sequence allows syn-syn polyketide fragments such as 7 to be obtained enantio and diastereoselectively. Enol Diisopinocampheylborinate is able to influence both the aldol and the subsequent reduction with NaBH4, via a chelate chair like intermediate.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/12030
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