(Chemical Equation Presented) No metal required: A protocol for the enantioselective organocatalytic chlorination of cyclic and acyclic Î²-keto esters and cyclic Î²-diketones has been developed which is also effective for the asymmetric bromination of Î²-keto esters. The methodology employs an inexpensive organocatalyst (e.g. benzoylquinidine) and polyhalogenated quinolinones as the source of the halogen (see scheme). Â© 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
|Titolo:||Organocatalytic asymmetric α-halogenation of 1,3-dicarbonyl compounds|
|Data di pubblicazione:||2005|
|Appare nelle tipologie:||1.1 Articolo in rivista|