(Chemical Equation Presented) The asymmetric aminolytic kinetic resolution (AKR) of racemic terminal epoxides using carbamates as the nucleophile catalyzed by (salen)CoIII complex provides a practical and straightforward method for the synthesis of both aliphatic and aromatic N-Boc- or N-Cbz-protected 1,2-amino alcohols in almost enantiomerically pure form (ee â¥ 99%). The AKR uses an easily accessible catalyst and inexpensive starting materials, and the reactions are conveniently carried out at room temperature under an air atmosphere.
|Titolo:||Asymmetric catalytic synthesis of enantiopure N-protected 1,2-amino alcohols|
|Data di pubblicazione:||2004|
|Appare nelle tipologie:||1.1 Articolo in rivista|