The tert-butoxy derivative is one of the most underused alcohol protecting groups. After having developed an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl3 and NaI in CH3CN. The procedure led to the successful cleavage of aliphatic and aromatic tert-butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule. Â© 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
|Titolo:||tert-butyl ethers: Renaissance of an alcohol protecting group. Facile cleavage with cerium(III) chloride/sodium iodide|
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||1.1 Articolo in rivista|