The tert-butoxy derivative is one of the most underused alcohol protecting groups. After having developed an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl3 and NaI in CH3CN. The procedure led to the successful cleavage of aliphatic and aromatic tert-butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
tert-butyl ethers: Renaissance of an alcohol protecting group. Facile cleavage with cerium(III) chloride/sodium iodide
Carlone, Armando;
2006-01-01
Abstract
The tert-butoxy derivative is one of the most underused alcohol protecting groups. After having developed an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl3 and NaI in CH3CN. The procedure led to the successful cleavage of aliphatic and aromatic tert-butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.File in questo prodotto:
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