Getting round the (periodic) table: A highly chemo- and enantioselective conjugate addition of diphenylphosphine to Î±,Î²-unsaturated aldehydes in the presence of a chiral secondary amine C provides a direct route to chiral Î²-phosphino aldehyde intermediates (see scheme, TMS = trimethylsilyl). The synthetic utility of the strategy was exemplified in a rapid one-pot (two-step) synthesis of highly enantioenriched 3-amino-phosphines. Â© 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
|Titolo:||Organocatalytic asymmetric hydrophosphination of α,β-unsaturated aldehydes|
|Data di pubblicazione:||2007|
|Appare nelle tipologie:||1.1 Articolo in rivista|