(Chemical Equation Presented) Nature, our teacher! The natural alkaloids quinine (Q) and quinidine (QD) serve as efficient bifunctional organocatalysts in the asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides (see scheme). Very high selectivity is observed in this one-step construction of highly functionalized compounds with two adjacent stereogenic centers from commercially available precursors. R1,R3 = alkyl, aryl, O-alkyl; R2 = alkyl, Bn; R4 = Bn. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Organocatalytic asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides
Carlone, Armando;
2006-01-01
Abstract
(Chemical Equation Presented) Nature, our teacher! The natural alkaloids quinine (Q) and quinidine (QD) serve as efficient bifunctional organocatalysts in the asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides (see scheme). Very high selectivity is observed in this one-step construction of highly functionalized compounds with two adjacent stereogenic centers from commercially available precursors. R1,R3 = alkyl, aryl, O-alkyl; R2 = alkyl, Bn; R4 = Bn. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.File in questo prodotto:
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