(Chemical Equation Presented) Nature, our teacher! The natural alkaloids quinine (Q) and quinidine (QD) serve as efficient bifunctional organocatalysts in the asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides (see scheme). Very high selectivity is observed in this one-step construction of highly functionalized compounds with two adjacent stereogenic centers from commercially available precursors. R1,R3 = alkyl, aryl, O-alkyl; R2 = alkyl, Bn; R4 = Bn. Â© 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
|Titolo:||Organocatalytic asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides|
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||1.1 Articolo in rivista|