The problem of simultaneous mass transfer and product-inhibited enzyme kinetics in porous slabs was numerically solved. Effectiveness factor and overall reaction rate were evaluated as function of physical and kinetic parameters. The study was mainly focused on the linear mixed-type product inhibition pattern. It was proved that, independently of the Thiele modulus, uncertainty exists in identifying the inhibition mechanism in the case of entrapped enzymes. Unexpected behaviors of the observable rate of reaction were pointed out and the possibility was presented of optimizing product formation per unit biocatalyst weight by appropriately selecting substrate conversion, i.e. concentrations of reactant and product in the liquid phase bathing the external particle surface

On the effectiveness factor of immobilized enzymes with linear mixed-type product inhibition kinetics

CANTARELLA, Maria;GALLIFUOCO, ALBERTO;
1995

Abstract

The problem of simultaneous mass transfer and product-inhibited enzyme kinetics in porous slabs was numerically solved. Effectiveness factor and overall reaction rate were evaluated as function of physical and kinetic parameters. The study was mainly focused on the linear mixed-type product inhibition pattern. It was proved that, independently of the Thiele modulus, uncertainty exists in identifying the inhibition mechanism in the case of entrapped enzymes. Unexpected behaviors of the observable rate of reaction were pointed out and the possibility was presented of optimizing product formation per unit biocatalyst weight by appropriately selecting substrate conversion, i.e. concentrations of reactant and product in the liquid phase bathing the external particle surface
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/12186
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact