The evolution of microcirculatory methods and the definition of the concept of venous microangiopathy allow the study in a quantitative way of microcirculatory changes produced by pharmacologic treatments at the areas most frequently and severely affected by chronic venous insufficiency (CVI), venous hypertensive microangiopathy, and venous ulcerations. This pilot study compares subjects with CVI, in the area most affected by venous hypertension in a 2-week registry. Elastic compression, compression plus ViatrombÂ® (lyposomal spray gel heparin), LiotonÂ® (gel including heparin), and ViatrombÂ® alone were compared. Subjects were evaluated for laser Doppler flux, transcutaneous partial pressure of oxygen (TcPO2), and partial pressure of carbon dioxide (PCO2) and CVI analogic symptom scale. In the ViatrombÂ® groups (B and D), significant decreases in laser Doppler flux, PCO2, and CVI score were observed. The decrease was proportionally more important in the elastic compression plus ViatrombÂ® group. Partial pressure of oxygen (PO2) was significantly increased. No significant changes were observed in the LiotonÂ® group. There was a good effect for compression only. These differences are significant, as they can be observed even in small groups (10-15 patients). No treatment side effects were observed, and compliance and tolerability were very good. Â©2007 Sage Publications.
|Titolo:||Microcirculatory effects of ViatrombÂ® spray gel heparin in chronic venous insufficiency: Evaluation of TcPO2 and PCO2 - A product evaluation study|
|Data di pubblicazione:||2007|
|Appare nelle tipologie:||1.1 Articolo in rivista|