A novel, efficient, and mild synthetic route for the preparation of 2-aminoquinolines via a gold-catalyzed cascade reaction of β-(2-aminophenyl)-α,β-ynones with ynamides has been developed. This process tolerates a wide range of functionalities such as halogen, alkyl, aryl, and heteroaryl groups, leading to original heterocycles in fair to very good yields.
Gold-Catalyzed Cascade Reaction of β‑(2-Aminophenyl)-α,β-ynones with Ynamides: A Sequential Route to Polysubstituted 2‑Aminoquinolines
Navnath D. RodeMembro del Collaboration Group
;Antonio Arcadi
;Antonella Di NicolaMembro del Collaboration Group
;Fabio MarinelliMembro del Collaboration Group
;
2018-01-01
Abstract
A novel, efficient, and mild synthetic route for the preparation of 2-aminoquinolines via a gold-catalyzed cascade reaction of β-(2-aminophenyl)-α,β-ynones with ynamides has been developed. This process tolerates a wide range of functionalities such as halogen, alkyl, aryl, and heteroaryl groups, leading to original heterocycles in fair to very good yields.File in questo prodotto:
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