We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobacter cloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. The microorganism was investigated for the presence of metallo- and extended-spectrum β-lactamases. The strain produced two class 1 integrons carrying blaVIM-1 and aadA2 gene cassettes located on chromosomal and plasmidic DNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum β-lactamase. Our results clearly demonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications. © Copyright 2008, Mary Ann Liebert, Inc.
Class I Integron-Borne bla(VIM-1) Carbapenemase in a Strain of Enterobacter cloacae Responsible for a Case of Fatal Pneumonia
PERILLI, MARIAGRAZIA;PELLEGRINI C;AMICOSANTE, Gianfranco;
2008-01-01
Abstract
We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobacter cloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. The microorganism was investigated for the presence of metallo- and extended-spectrum β-lactamases. The strain produced two class 1 integrons carrying blaVIM-1 and aadA2 gene cassettes located on chromosomal and plasmidic DNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum β-lactamase. Our results clearly demonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications. © Copyright 2008, Mary Ann Liebert, Inc.Pubblicazioni consigliate
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