An advection–diffusion–reaction transport model for a continuous reactor characterized by a simple geometry is simulated to provide a design guidance for the realization of an optimized experimental prototype consisting of a rectangular channel hosting a scaffold slab that provides an immobilizing support for the cells. A counter-current carrier flow crossing the channel feeds the oxygen and growth factors and ensures the removal of metabolic products. A more complex sinusoidal configuration, which has been recently used as for hepatocyte culture, is proposed and evaluated. Silico tests shows how the designed device is able to replicate the endothelial–parenchymal interface of a liver sinusoid.

Design of microfluidic bioreactors: Transport regimes

Marina Prisciandaro;
2018-01-01

Abstract

An advection–diffusion–reaction transport model for a continuous reactor characterized by a simple geometry is simulated to provide a design guidance for the realization of an optimized experimental prototype consisting of a rectangular channel hosting a scaffold slab that provides an immobilizing support for the cells. A counter-current carrier flow crossing the channel feeds the oxygen and growth factors and ensures the removal of metabolic products. A more complex sinusoidal configuration, which has been recently used as for hepatocyte culture, is proposed and evaluated. Silico tests shows how the designed device is able to replicate the endothelial–parenchymal interface of a liver sinusoid.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/127955
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact