Sequential Brønsted acid promoted amination/annulation/aromatization of β-(2-aminophenyl)-α,β-ynones with cyclic α-methylene carbonylcompounds has been developed for the synthesis of polycyclic quinolines in good to high yields in ethanol. The protocol achieves the selective formation of the target quinolines and is expected to find practical applications due to its operational simplicity.

Synthesis of Polycyclic Quinolines by Means of Brønsted Acid Mediated Reaction of β-(2-Aminophenyl)-α,β-Ynones with Ketones

MARSICANO, VINCENZO;Marco Chiarini;Fabio Marinelli;Antonio Arcadi
2019

Abstract

Sequential Brønsted acid promoted amination/annulation/aromatization of β-(2-aminophenyl)-α,β-ynones with cyclic α-methylene carbonylcompounds has been developed for the synthesis of polycyclic quinolines in good to high yields in ethanol. The protocol achieves the selective formation of the target quinolines and is expected to find practical applications due to its operational simplicity.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/134515
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