Sequential Brønsted acid promoted amination/annulation/aromatization of β-(2-aminophenyl)-α,β-ynones with cyclic α-methylene carbonylcompounds has been developed for the synthesis of polycyclic quinolines in good to high yields in ethanol. The protocol achieves the selective formation of the target quinolines and is expected to find practical applications due to its operational simplicity.
Synthesis of Polycyclic Quinolines by Means of Brønsted Acid Mediated Reaction of β-(2-Aminophenyl)-α,β-Ynones with Ketones
MARSICANO, VINCENZO;Marco Chiarini;Fabio Marinelli;Antonio Arcadi
2019-01-01
Abstract
Sequential Brønsted acid promoted amination/annulation/aromatization of β-(2-aminophenyl)-α,β-ynones with cyclic α-methylene carbonylcompounds has been developed for the synthesis of polycyclic quinolines in good to high yields in ethanol. The protocol achieves the selective formation of the target quinolines and is expected to find practical applications due to its operational simplicity.File in questo prodotto:
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