Mir-23b and miR-130b expression is downregulated in pituitary adenomas

Leone, V; Langella, C; D'Angelo, D; Mussnich, P; Wierinckx, A; Terracciano, L; Raverot, G; Lachuer, J; Rotondi, S; Jaffrain, Marie Lise; Trouillas, J; Fusco, A.

doi:10.1016/j.mce.2014.03.002

MicroRNA (miRNA) deregulation plays a critical role in tumorigenesis. miR-23b and miR-130b are induced by thyrotropin in thyroid cells in a cAMP-dependent manner. The aim of our work has been to investigate the possible role of miR-23b and miR-130b in pituitary tumorigenesis. We have analyzed their expression in a panel of pituitary adenomas (PAs) including GH and NFPA adenomas. We report that miR-23b and miR-130b are drastically reduced in GH, gonadotroph and NFPA adenomas in comparison with normal pituitary gland. Interestingly, the overexpression of miR-23b and miR-130b inhibits cell proliferation arresting the cells in the G1 and G2 phase of the cell cycle, respectively. Moreover, we demonstrate that miR-23b and miR-130b target HMGA2 and cyclin A2 (CCNA2) genes, respectively. Finally, downregulation of miR-23b and miR-130b expression is associated with increased levels of their respective targets in human PAs. These findings suggest that miR-23b and miR-130b downregulation may contribute to pituitary tumorigenesis.

Titolo:	Mir-23b and miR-130b expression is downregulated in pituitary adenomas
Autori:	Leone V Langella C D'Angelo D Mussnich P Wierinckx A Terracciano L Raverot G Lachuer J Rotondi S JAFFRAIN, MARIE LISE Trouillas J Fusco A. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	MOLECULAR AND CELLULAR ENDOCRINOLOGY
Abstract:	MicroRNA (miRNA) deregulation plays a critical role in tumorigenesis. miR-23b and miR-130b are induced by thyrotropin in thyroid cells in a cAMP-dependent manner. The aim of our work has been to investigate the possible role of miR-23b and miR-130b in pituitary tumorigenesis. We have analyzed their expression in a panel of pituitary adenomas (PAs) including GH and NFPA adenomas. We report that miR-23b and miR-130b are drastically reduced in GH, gonadotroph and NFPA adenomas in comparison with normal pituitary gland. Interestingly, the overexpression of miR-23b and miR-130b inhibits cell proliferation arresting the cells in the G1 and G2 phase of the cell cycle, respectively. Moreover, we demonstrate that miR-23b and miR-130b target HMGA2 and cyclin A2 (CCNA2) genes, respectively. Finally, downregulation of miR-23b and miR-130b expression is associated with increased levels of their respective targets in human PAs. These findings suggest that miR-23b and miR-130b downregulation may contribute to pituitary tumorigenesis.
Handle:	http://hdl.handle.net/11697/13862
Appare nelle tipologie:	1.1 Articolo in rivista

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