8 Tesi di dottorato

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8.1 Tesi di dottorato 366

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Aspetti biomolecolari dei gliomi maligni “Caratterizzazione biomolecolare di gliomi ad alto grado di malignità: analisi dei meccanismi alla base della resistenza alle terapie"

I gliomi sono forme cancerose di cellule gliali e rappresentano i tumori primari più comuni del sistema nervoso centrale, associati a una significativa mortalità. Dopo i traumi cranici, costituiscono la seconda causa di morte per malattie neurologiche e sono particolarmente difficili da trattare a causa della loro elevata malignità, invasività e resistenza alle terapie convenzionali. Proprio l’elevata eterogeneità molecolare rilevata nei gliomi è alla base della nota resistenza di tali tumor...

Eccezionale e standard. Un’ipotesi tipologica sul personaggio del romanzo ipercontemporaneo

This work aims to analyse the concept of the typical character in the contemporary novel. It will argue that some novels from the past thirty years consciously reflect on this concept, proposing a typical character that is no longer built on the metonymic relationship between the particular and the general, as was common in the 19th century, but rather on the dialectical relationship between the exceptional and the standard. I will demonstrate this through the analysis of three novels (in add...

Tecniche avanzate di riduzione dell'ordine del modello di modelli PEEC ritardati

The partial element equivalent circuit (PEEC) method is a widely recognized electromagnetic computational technique due to its ability to represent electromagnetic phenomena using equivalent circuits. It is a popular technique in electromagnetic compatibility (EC) analysis, antenna, and interconnect design. Quasi-static PEEC models are represented by a set of ordinary differential equations (ODEs). However, delayed PEEC models are better suited for accurately capturing the behavior of comple...

Applicazione di approcci tecnologici avanzati per l’analisi della qualità e della diversità biologica nei tartufi

Truffles of the genus Tuber are highly valued fungi that host complex biological communities and undergo post-harvest transformations affecting their quality and shelf life. This study applies advanced technological approaches to investigate truffle quality and biological diversity, integrating quantitative Magnetic Resonance Imaging (QMRI) with ecological and microbiological analyses. QMRI was used to monitor mass, volume, and water content variations in Tuber aestivum, Tuber melanosporum, a...

Intelligenza artificiale e nanomedicine teranostiche funzionalizzate con peptidi targettanti per il trattamento selettivo del glioblastoma

Nanomedicine has revolutionized oncology by leveraging nanoscale materials to enhance drug delivery, optimize pharmacokinetics, and minimize systemic toxicity. A key advantage of this technology is the ability to functionalize nanoparticles with targeting moieties, such as peptides, antibodies, or small molecules, enabling selective drug accumulation in pathological tissues. This targeted strategy not only improves therapeutic efficacy but also minimizes off-target effects, thereby improving ...

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