Effect of 17β-estradiol, progesterone and tamoxifen on in vitro  proliferation of human pituitary adenomas. Correlation with specific cellular receptors

Caronti, B; Palladini, G; Bevilacqua, Mg; Petrangeli, E; Fraioli, B; Cantore, G; Tamburrano, G; JAFFRAIN-REA, M.L.

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Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17 beta-estradiol (17 beta-E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17 beta-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/14362

Titolo:	Effect of 17β-estradiol, progesterone and tamoxifen on in vitro proliferation of human pituitary adenomas. Correlation with specific cellular receptors
Autori interni:	JAFFRAIN, MARIE LISE
Data di pubblicazione:	1993
Rivista:	TUMOR BIOLOGY
Abstract:	Six human pituitary adenoma cultures, characterized for estrogen and progesterone (Pg) receptors, were treated with 17 beta-estradiol (17 beta-E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in most cases a stimulating effect of 17 beta-E2 and an inhibitory effect of Pg on cell growth, which appeared to be correlated with specific receptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.
Handle:	http://hdl.handle.net/11697/14362
Appare nelle tipologie:	1.1 Articolo in rivista

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