The palladium-catalyzed reaction of aryl iodides with tertiary propargylic amides affords highly substituted allenes. Best results have been obtained by using Pd(OAc)(2), "Bu3N, HCOOH, and "Bu4NCl or LiCl in DME at 100 degreesC. The reaction is highly regioselective and the carbopalladation step is controlled by the strong directing effect of the tertiary amide group.
Palladium-catalyzed reaction of aryl iodides with tertiary propargylamides. Highly substituted allenes through a regioselective carbopalladation/b-NPd elimination reaction
A. ARCADI;MARINELLI, Fabio;
2003
Abstract
The palladium-catalyzed reaction of aryl iodides with tertiary propargylic amides affords highly substituted allenes. Best results have been obtained by using Pd(OAc)(2), "Bu3N, HCOOH, and "Bu4NCl or LiCl in DME at 100 degreesC. The reaction is highly regioselective and the carbopalladation step is controlled by the strong directing effect of the tertiary amide group.File in questo prodotto:
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