In this article we have disclosed a combination of versatile methodologies for the asymmetric synthesis and manipulation of isoindolinones and fused benzo-indolizidinones. On one hand, two consecutive asymmetric cascade reactions allow the synthesis of isoindolinones and fused benzo-indolizidinones, with the stereoselective construction of up to three stereocenters. On the other hand the study of the heterochiral crystallization and the easy functionalization of the obtained molecular platforms render the chemistry of these heterocyclic compounds particularly useful.
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