New heterocyclic hybrids were synthesized in an aldol initiated organocascade reaction of nucleophilic isoindolinones with 2-formyl benzonitriles (2-cyano benzaldehydes). Excellent diastereo- and enantioselectivities and good yields were obtained in the presence of bifunctional organocatalysts. In addition, a new application of the Staudinger reaction has been proposed for the synthesis of substituted nucleophilic isoindolinones
Highly diastereo- and enantioselective organocatalytic synthesis of new heterocyclic hybrids isoindolinone-imidate and isoindolinone-phthalide
Palombi Laura;
2016-01-01
Abstract
New heterocyclic hybrids were synthesized in an aldol initiated organocascade reaction of nucleophilic isoindolinones with 2-formyl benzonitriles (2-cyano benzaldehydes). Excellent diastereo- and enantioselectivities and good yields were obtained in the presence of bifunctional organocatalysts. In addition, a new application of the Staudinger reaction has been proposed for the synthesis of substituted nucleophilic isoindolinonesFile in questo prodotto:
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