Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-
      naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte 
      elastase

Arcadi, A.; Asti, C.; Brandolini, L.; Caselli, G.; Marinelli, Fabio; Ruggeri, V.

doi:10.1016/S0960-894X(99)00168-7

2-vinyl-4H-3,1-benzoxazin-4-one has been synthesised and tested for inhibitory activity against human leukocyte elastase. The compound has shown activity both in vitro towards human sputum elastase and in vivo in an hemorrhagic assay.

Titolo:	Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'- naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase
Autori:	ARCADI, Antonio C. ASTI L. BRANDOLINI G. CASELLI MARINELLI, Fabio V. RUGGERI mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract:	2-vinyl-4H-3,1-benzoxazin-4-one has been synthesised and tested for inhibitory activity against human leukocyte elastase. The compound has shown activity both in vitro towards human sputum elastase and in vivo in an hemorrhagic assay.
Handle:	http://hdl.handle.net/11697/14907
Appare nelle tipologie:	1.1 Articolo in rivista

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