The palladium-catalyzed hydroarylation and hydrovinylation of tertiary 3-(o-acetoxyaryl)- and 3-(o-benzoyloxyaryl) propynols provides a regio- and stereoselective route to allylic alcohols with aryl and vinyl substituents which can be readily converted into the corresponding chromene derivatives. The hydroarylation and hydrovinylation reaction is believed to proceed through a carbopalladation step whose regiochemistry is primarily controlled by the directing effect of the tertiary hydroxy group.
The palladium-catalyzed hydroarylation and hydrovinylation of tertiary 3-(o-acetoxyaryl)- and 3-(o-benzoyloxyaryl)propinols- a route to 4-aryl- and 4- vinyl-2,2-dimethyl-3-chromenes
A. ARCADIMembro del Collaboration Group
;MARINELLI, Fabio
Membro del Collaboration Group
;
2000-01-01
Abstract
The palladium-catalyzed hydroarylation and hydrovinylation of tertiary 3-(o-acetoxyaryl)- and 3-(o-benzoyloxyaryl) propynols provides a regio- and stereoselective route to allylic alcohols with aryl and vinyl substituents which can be readily converted into the corresponding chromene derivatives. The hydroarylation and hydrovinylation reaction is believed to proceed through a carbopalladation step whose regiochemistry is primarily controlled by the directing effect of the tertiary hydroxy group.File in questo prodotto:
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