The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process.
Synthesis of 2-acyl and 2-ethoxycarbonyl-3-alkylindoles from o- allkynyltrifluoroacetanilides
A. ARCADI;MARINELLI, Fabio
2000
Abstract
The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process.File in questo prodotto:
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