The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process.

Synthesis of 2-acyl and 2-ethoxycarbonyl-3-alkylindoles from o- allkynyltrifluoroacetanilides

A. ARCADI;MARINELLI, Fabio
2000

Abstract

The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/14916
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