The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process.
Titolo: | Synthesis of 2-acyl and 2-ethoxycarbonyl-3-alkylindoles from o- allkynyltrifluoroacetanilides |
Autori: | |
Data di pubblicazione: | 2000 |
Rivista: | |
Abstract: | The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or alpha-bromoketones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process. |
Handle: | http://hdl.handle.net/11697/14916 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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