CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
Englishbeta-(2-aminophenyl)-alpha,beta-ynones can quickly give functionalized 2,4-disubstituted quinolines through tandem nucleophic addition/annulations reactions. Acid-catalysed cyclization of beta-(2-aminophenyl)-alpha,beta-ynones can also occur. The easy entry into 4-iodo-2-substituted-quinolines prompted the development of a one pot procedure for synthesis of 2,4-disubstituted quinolines by further elaboration by means of palladium-catalysed reactions. The exposure to basic conditions of one beta-(2-malonylamidophenyl)-alpha,beta-ynone led to a fused quinolone derivative through intramolecular Michael addition /tautomerisation/transesterification cascade reactions. Fused polycyclic quinolines can be viewed as occurring through a tandem concerted Diels-Alder/annulation reactions of beta-(2-aminophenyl)-alpha,beta-ynones with enamines, azides and nitrile oxides.
| Titolo: | Synthesis of Functionalised Quinolines through Tandem Addition/Annulation Reactions of b-(2-Aminophenyl)-a,b-ynones | |
| Autori: | ||
| Data di pubblicazione: | 1999 | |
| Rivista: | ||
| Abstract: | beta-(2-aminophenyl)-alpha,beta-ynones can quickly give functionalized 2,4-disubstituted quinolines through tandem nucleophic addition/annulations reactions. Acid-catalysed cyclization of beta-(2-aminophenyl)-alpha,beta-ynones can also occur. The easy entry into 4-iodo-2-substituted-quinolines prompted the development of a one pot procedure for synthesis of 2,4-disubstituted quinolines by further elaboration by means of palladium-catalysed reactions. The exposure to basic conditions of one beta-(2-malonylamidophenyl)-alpha,beta-ynone led to a fused quinolone derivative through intramolecular Michael addition /tautomerisation/transesterification cascade reactions. Fused polycyclic quinolines can be viewed as occurring through a tandem concerted Diels-Alder/annulation reactions of beta-(2-aminophenyl)-alpha,beta-ynones with enamines, azides and nitrile oxides. | |
| Handle: | http://hdl.handle.net/11697/14917 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11697/14917
Copyright © 2021