Not so complex: The asymmetric one-step construction of multiple stereocenters in complex spirocyclic oxindoles was achieved with very high fidelity by using distinct organocascade reactions utilizing two organocatalysts, each activating different carbonyl compounds (see scheme; TMS=trimethylsilyl). The complementary approaches demonstrate the potential of organocascade catalysis to face challenging synthetic problems. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.
Targeting structural and stereochemical complexity by organocascade catalysis: construction of spirocyclic oxindoles having multiple stereocenters
Pesciaioli F.;
2009-01-01
Abstract
Not so complex: The asymmetric one-step construction of multiple stereocenters in complex spirocyclic oxindoles was achieved with very high fidelity by using distinct organocascade reactions utilizing two organocatalysts, each activating different carbonyl compounds (see scheme; TMS=trimethylsilyl). The complementary approaches demonstrate the potential of organocascade catalysis to face challenging synthetic problems. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.File in questo prodotto:
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