Not so complex: The asymmetric one-step construction of multiple stereocenters in complex spirocyclic oxindoles was achieved with very high fidelity by using distinct organocascade reactions utilizing two organocatalysts, each activating different carbonyl compounds (see scheme; TMS=trimethylsilyl). The complementary approaches demonstrate the potential of organocascade catalysis to face challenging synthetic problems. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

Targeting structural and stereochemical complexity by organocascade catalysis: construction of spirocyclic oxindoles having multiple stereocenters

Pesciaioli F.;
2009-01-01

Abstract

Not so complex: The asymmetric one-step construction of multiple stereocenters in complex spirocyclic oxindoles was achieved with very high fidelity by using distinct organocascade reactions utilizing two organocatalysts, each activating different carbonyl compounds (see scheme; TMS=trimethylsilyl). The complementary approaches demonstrate the potential of organocascade catalysis to face challenging synthetic problems. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/150172
Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 418
  • ???jsp.display-item.citation.isi??? 404
social impact