Time to α-branch out! The first highly enantioselective aminocatalytic activation of a-substituted αβ-unsaturated aldehydes is presented. The chiral primary amine 1 selectively activates ct-branched enals toward a well-defined iminium ion enamine reaction sequence for both Friedel-Crafts/amination and sulfa-Michael/ amination cascades. The valuable multifunctional products, having two contiguous sterocenters, are isolated in high enantiomeric purity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
|Titolo:||Asymmetric organocatalytic cascade reactions with a-substituted α,β-unsaturated aldehydes|
|Data di pubblicazione:||2009|
|Appare nelle tipologie:||1.1 Articolo in rivista|