A primary amine derived from cinchona alkaloids as a salt with d-N-Boc phenylglycine (Boc = tert-butoxycarbonyl) is an efficient catalyst for the aziridination of α,β-unsaturated ketones. This method is effective with both linear and cyclic substrates, leading to chiral aziridines in high yield, with complete diastereoselectivity, and with very high enantioselectivity (Cbz = benzyloxycarbonyl). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Organocatalytic asymmetric aziridination of enones
Pesciaioli F.;
2008-01-01
Abstract
A primary amine derived from cinchona alkaloids as a salt with d-N-Boc phenylglycine (Boc = tert-butoxycarbonyl) is an efficient catalyst for the aziridination of α,β-unsaturated ketones. This method is effective with both linear and cyclic substrates, leading to chiral aziridines in high yield, with complete diastereoselectivity, and with very high enantioselectivity (Cbz = benzyloxycarbonyl). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.File in questo prodotto:
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