Clinical Trial on Aveeno Skin Relief Moisturizing Lotion in patients with itching accompanied by skin lesions and xerosis

Background: Itch associated with cutaneous xerosis is a common condition, which can be effectively treated with the use of emollients combined with hydration therapy. The aim of our study was to evaluate the efficacy and tolerability of a new lotion containing menthol and colloidal oatmeal in patients with itch and cutaneous xerosis. Patients and Methods: Fifty-four patients with pruritus of different origin associated with lesions as erythema, desquamation, scratching, and lichenization were treated with Aveeno Skin Relief Moisturizing Lotion once daily for 3 weeks. Efficacy and tolerability were evaluated by comparison of changes from baseline in clinical appearance, hydration, and pH. Results: After treatment, clinical examination, and the self-administered questionnaire revealed a significant improvement of cutaneous lesions including erythema, scaling, scratching lesions, lichenization, and pruritus in 52 of 54 treated patients (96%). Complete regression of cutaneous lesions and pruritus was achieved in 48 of 54 (88.9%) patients; whereas a partial remission was observed in 4/54 (7.4%) subjects and no improvement in 2/54 (3.7%) subjects. An increase of cutaneous hydration of 35.9% after 1 week treatment and of 45.7% after 3 weeks treatment was observed; those increments were associated with a simultaneous decrease of cutaneous pH: -4.0% after one week and -6.3% after 3 weeks treatment. The lotion was well tolerated by all patients. Conclusions. Based on our experience, Aveeno Skin Relief Moisturizing Lotion appears to be an effective moisturizing emollient that reduces pruritus in subjects with xerosis.