Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

Batkai, S; Mukhopadhyay, P; Horvath, B; Rajesh, M; R Y, Gao; Mahadevan, A; Amere, M; Battista, N; A H, Lichtman; L A, Gauson; Maccarrone, M; R G, Pertwee; Pacher, P

doi:10.1111/j.1476-5381.2011.01410.x

Activation of cannabinoid CB2 receptors protects against various forms of ischaemia-reperfusion (I/R) injury. Delta(8)-Tetrahydrocannabivarin (Delta(8)-THCV) is a synthetic analogue of the plant cannabinoid Delta(9)-tetrahydrocannabivarin, which exhibits anti-inflammatory effects in rodents involving activation of CB2 receptors. Here, we assessed effects of Delta(8)-THCV and its metabolite 11-OH-Delta(8)-THCV on CB2 receptors and against hepatic I/R injury.

Titolo:	Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors
Autori:	Batkai S Mukhopadhyay P Horvath B Rajesh M Gao R Y Mahadevan A Amere M Battista N Lichtman A H Gauson L A MACCARRONE, Mauro Pertwee R G Pacher P mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2012
Rivista:	BRITISH JOURNAL OF PHARMACOLOGY
Handle:	http://hdl.handle.net/11697/155938
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11697/155938

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