Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

F S, den Boon; Chameau, P; Schaafsma-Zhao, Q; van Aken, W; Bari, M; Oddi, So; C G, Kruse; Maccarrone, M; W J, Wadman; T R, Werkman

doi:10.1073/pnas.1118167109

The endocannabinoid (eCB) system is widely expressed throughout the central nervous system (CNS) and the functionality of type-1 cannabinoid receptors in neurons is well documented. In contrast, there is little knowledge about type-2 cannabinoid receptors (CB(2)Rs) in the CNS. Here, we show that CB(2)Rs are located intracellularly in layer II/III pyramidal cells of the rodent medial prefrontal cortex (mPFC) and that their activation results in IP3R-dependent opening of Ca2+-activated Cl- channels. To investigate the functional role of CB2R activation, we induced neuronal firing and observed a CB2R-mediated reduction in firing frequency. The description of this unique CB2R-mediated signaling pathway, controlling neuronal excitability, broadens our knowledge of the influence of the eCB system on brain function.

Titolo:	Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
Autori:	den Boon F S Chameau P Schaafsma-Zhao Q van Aken W Bari M Oddi So Kruse C G MACCARRONE, Mauro Wadman W J Werkman T R mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2012
Rivista:	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Handle:	http://hdl.handle.net/11697/155990
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11697/155990

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