Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

Ferri, E; Arosio, B; D'Addario, C; Galimberti, D; Gussago, C; Pucci, M; Casati, M; Fenoglio, C; Abbate, C; Rossi, Pd; Scarpini, E; Maccarrone, M; Mari, D

doi:10.1016/j.jns.2016.02.004

Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

Titolo:	Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease
Autori:	Ferri E Arosio B D'Addario C Galimberti D Gussago C Pucci M Casati M Fenoglio C Abbate C Rossi PD Scarpini E MACCARRONE, Mauro Mari D mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Rivista:	JOURNAL OF THE NEUROLOGICAL SCIENCES
Abstract:	Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
Handle:	http://hdl.handle.net/11697/156043
Appare nelle tipologie:	1.1 Articolo in rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11697/156043

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CINECA IRIS Institutional Research Information System

File in questo prodotto: